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GPER is highly expressed in brown adipocytes, and its levels are closely correlated with the functional state of adipose tissue [211, 212]

Although not extensively studied, these findings suggest that the gut microbiota may influence NOferroptosis crosstalk through metabolic pathways, warranting further investigation

Among the bioactive constituents of the Nigella sativa , TQ is widely recognized as the principal compound that is responsible for many of its neuroprotective properties

Hydration and gradual dose escalation may minimize this concern

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